Acute decompression illness and serum s100beta levels: a prospective observational pilot study.

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Acute decompression illness and serum s100beta levels: a prospective observational pilot study.

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Title: Acute decompression illness and serum s100beta levels: a prospective observational pilot study.
Author: Poff, DJ; Wong, R; Bulsara, M
Abstract: BACKGROUND: S100beta, a calcium binding protein associated with astroglial cells and other tissues has been shown to be raised in the serum of patients with a number of neurological pathologies. As there are no published data on serum S100beta determinations in recreational divers affected by decompression illness (DCI) this pilot study determines whether S100beta is a possible biochemical marker of DCI worthy of further investigation. METHODS: Venous blood samples were drawn from patients diagnosed with, and treated for acute DCI at a hyperbaric facility and analysed for serum S100beta concentration and Creatine Kinase (CK) activity. Samples were taken at initial presentation, and again following final treatment. RESULTS: Twenty one patients were included in the study. Neither S100beta, nor CK levels were significantly raised above population normal limits. CONCLUSION: S100beta is not a clinically useful serum marker of acute DCI.
Description: Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc.
URI: http://archive.rubicon-foundation.org/8036
Date: 2007

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